DAXX anticorps

N° du produit ABIN1843310

L’anticorps Souris Monoclonal anti-DAXX a été validé pour WB, ELISA, FACS et IF/ICC. Il convient pour détecter DAXX dans des échantillons de Humain.

Aperçu rapide pour DAXX anticorps (ABIN1843310)

Antigène: DAXX (Death-Domain Associated Protein (DAXX))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp DAXX est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (fixed cells) (IF/ICC)

Détail du produit anti-DAXX anticorps

Purification: Purified by Protein G affinity chromatography

Immunogène: Purified recombinant fragment of human DAXX expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol and 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.

Détails sur DAXX

Antigène: DAXX (Death-Domain Associated Protein (DAXX))

Autre désignation: DAXX

Sujet: Daxx is a transcriptional co-regulatory protein. Proposed to mediate activation of the JNK pathway and apoptosis via ASK1 in response to signaling from FAS and TGF beta R2. Glucose deprivation activates the ASK1-SEK1-JNK1-HIPK1 pathway, relocalizing Daxx from the nucleus to the cytoplasm, where Daxx binds to ASK1, and subsequently leads to ASK1 oligomerization. Interaction with HSP27 may prevent interaction with TGF beta R2 and ASK1 and block DAXX-mediated apoptosis. Seems to act as a transcriptional co- repressor and inhibits PAX3 and ETS1 through direct protein- protein interaction. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Two alternatively spliced isoforms have been described.

Poids moléculaire: 81 kDa

ID gène: 1616

UniProt: Q9UER7

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway